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HYDROBIOME SERUM
50 ml / 1.7 fl oz | 10 Ingredients
The EPICUTIS® Hydrobiome Serum is an EWG Verified (pending) formulation designed to improve overall skin health through balancing the microbiome and strengthening the skin barrier. This advanced formula combines two clinically proven actives — TCP, a patented, TLR2 modulator developed by Signum Biosciences that calms irritation and targets C. acnes and TPNa, a next-generation, form of water-soluble Vitamin E chosen for its antioxidant protection and ability to strengthen the skin barrier.
TCP works harmoniously within the skin’s microbiome, helping to calm visible irritation while supporting the balance of beneficial flora essential for healthy skin. Combined with TPNa's strengthening of the skin barrier, this formulation is ideal for any barrier damage or general maintenance. These ingredients soothe discomfort, promote microbiome equilibrium, and reinforce the skin barrier for visibly clearer, calmer, and more resilient skin.
Lightweight and fast-absorbing, the Hydrobiome Serum delivers a refined, soothing experience that nurtures long-term skin health and balance in your microbiome.
Balancing, Calming + Strengthening Ingredients:
TCP to balance the microbiome + calm inflammation
TPNa provides anti-oxidant protection
Sodium Hyaluronate to instantly boost skin's moisture level
Propanediol for skin plumping + anti-microbial benefits
How To Use
Apply two pumps of serum to clean fingertips. Gently spread it evenly over your face until it is fully absorbed. For your neck and décolleté, use an additional pump. For optimal results, use morning and night.
INGREDIENTS:
Pentylene Glycol
Pentylene Glycol is a plant-derived diol that functions as a humectant and solvent to attract moisture, stabilize emulsions and boost preservative performance in skincare formulations. Its antimicrobial properties and low molecular weight support hydration, texture enhancement and ingredient delivery without irritating sensitive skin.
Sodium Hyaluronate
Sodium Hyaluronate is the sodium salt of hyaluronic acid that penetrates deeply to bind moisture, plump skin, and smooth fine lines. It forms a protective, lightweight film to reduce water loss and calm inflammation, making it an essential humectant for dry, sensitive, and aging skin in serums, creams, and masks.
Propanediol
Propanediol is a corn-derived humectant and solvent that boosts hydration, smooths texture, and supports the skin barrier with a lightweight, non-sticky feel. It enhances ingredient penetration, improves preservative efficacy, and stabilizes formulations, serving as a sustainable alternative to propylene glycol for all skin types.
Glycerin
Glycerin is a powerful natural humectant that draws moisture to the skin, creating a lasting hydration reservoir. It penetrates through aquaporin-3 channels to strengthen the barrier, support cell membrane fluidity, and enhance other ingredients—making it ideal for dry, sensitive, or compromised skin and suitable for all skin types.
50 ml / 1.7 fl oz | 10 Ingredients
The EPICUTIS® Hydrobiome Serum is an EWG Verified (pending) formulation designed to improve overall skin health through balancing the microbiome and strengthening the skin barrier. This advanced formula combines two clinically proven actives — TCP, a patented, TLR2 modulator developed by Signum Biosciences that calms irritation and targets C. acnes and TPNa, a next-generation, form of water-soluble Vitamin E chosen for its antioxidant protection and ability to strengthen the skin barrier.
TCP works harmoniously within the skin’s microbiome, helping to calm visible irritation while supporting the balance of beneficial flora essential for healthy skin. Combined with TPNa's strengthening of the skin barrier, this formulation is ideal for any barrier damage or general maintenance. These ingredients soothe discomfort, promote microbiome equilibrium, and reinforce the skin barrier for visibly clearer, calmer, and more resilient skin.
Lightweight and fast-absorbing, the Hydrobiome Serum delivers a refined, soothing experience that nurtures long-term skin health and balance in your microbiome.
Balancing, Calming + Strengthening Ingredients:
TCP to balance the microbiome + calm inflammation
TPNa provides anti-oxidant protection
Sodium Hyaluronate to instantly boost skin's moisture level
Propanediol for skin plumping + anti-microbial benefits
How To Use
Apply two pumps of serum to clean fingertips. Gently spread it evenly over your face until it is fully absorbed. For your neck and décolleté, use an additional pump. For optimal results, use morning and night.
INGREDIENTS:
Pentylene Glycol
Pentylene Glycol is a plant-derived diol that functions as a humectant and solvent to attract moisture, stabilize emulsions and boost preservative performance in skincare formulations. Its antimicrobial properties and low molecular weight support hydration, texture enhancement and ingredient delivery without irritating sensitive skin.
Sodium Hyaluronate
Sodium Hyaluronate is the sodium salt of hyaluronic acid that penetrates deeply to bind moisture, plump skin, and smooth fine lines. It forms a protective, lightweight film to reduce water loss and calm inflammation, making it an essential humectant for dry, sensitive, and aging skin in serums, creams, and masks.
Propanediol
Propanediol is a corn-derived humectant and solvent that boosts hydration, smooths texture, and supports the skin barrier with a lightweight, non-sticky feel. It enhances ingredient penetration, improves preservative efficacy, and stabilizes formulations, serving as a sustainable alternative to propylene glycol for all skin types.
Glycerin
Glycerin is a powerful natural humectant that draws moisture to the skin, creating a lasting hydration reservoir. It penetrates through aquaporin-3 channels to strengthen the barrier, support cell membrane fluidity, and enhance other ingredients—making it ideal for dry, sensitive, or compromised skin and suitable for all skin types.

